Pyruvate carboxylase is an enzyme. Its role is to form oxaloacetate by the ATP dependent carboxylation
of pyruvate. To carboxylize means to add CO2 in order to produce a -COOH group. Once the oxaloacetate is formed it may
be used to produce glucose, neurotransmitter, or amino acids. Pyruvate carboxylase is a mitochondrial enzyme, and
can be found in the liver. The enzyme can be inhibited by a high intracellular concentration of ADP (which is what is left
after ATP is used for energy).
